Histology-specific FGFR2 alterations and FGFR2-TACC2 fusion in mixed adenoid cystic and neuroendocrine small cell carcinoma of the uterine cervix

Histology-specific FGFR2 alterations and FGFR2-TACC2 fusion in mixed adenoid cystic and neuroendocrine small cell carcinoma of the uterine cervix

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Neuroendocrine small cell carcinoma of the uterine cervix portends a dismal prognosis with limited treatment options.Rarely, tumors of mixed-lineage appear in gynecologic malignancies.Here, we report a 77-year-old woman who presented with complete uterine prolapse and 4-month history of vaginal bleeding.

Histopathologic evaluation revealed a mixed adenoid cystic carcinoma and neuroendocrine small cell carcinoma of jalkapallo asu the uterine cervix.The tumor was PD-L1 and HPV 35 positive.The patient was treated with up-front surgery and adjuvant radiation.

Independent, histology-specific alterations in FGFR2 and a FGFR2-TACC2 fusion were identified.Progression of disease occurred within 6 months for which she received chemotherapy and immunotherapy.However, the patient expired within a year.

We comprehensively biodegradable latex balloons review how screening for and targeting of FGFR alterations in recurrent and metastatic cervical cancer might serve as a touchstone for future treatment regimens.